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cadmium zinc metallothionein

Induction of metallothionein synthesis by zinc in cadmium ...

The ability of zinc (Zn) salts to induce the synthesis of metallothionein (MT) in liver, kidney and pancreas of rats pretreated with cadmium (Cd) salts was investigated. Twenty-four hours after either CdCl2 (2.0 mg Cd/kg, s.c.) or saline pretreatment, rats were injected with saline, CdCl2 (2.0 mg Cd

Cadmium, zinc, and copper in rabbit kidney metallothionein ...

The molar ratio of cadmium, zinc, and copper in metallothionein fractions from kidneys with different concentrations of cadmium was determined. At low concentrations of cadmium in rabbit kidneys, zinc was the dominating metal bound to metallothionein (70-90%).

Cadmium and zinc bioaccumulation and metallothionein ...

Oct 01, 2006 · This study was designed to compare the metallothionein (MT) response capacity of two freshwater bivalves, Corbicula fluminea and Dreissena polymorpha, along an environmental gradient of polymetallic pollution.The bivalves were transplanted into 4 stations in southwestern France, with a cadmium and zinc pollution gradient.

Single crystals of cadmium, zinc metallothionein.

THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 258: No, 10, Issue of May 25, pp. 6255-6257,1983 Printedm USA. Single Crystals of Cadmium, Zinc Metallothionein* (Received for publication, December 6, 1982) Karen A. Melis, Daniel C. Carter, and Charles David Stout$ From the Department of Crystallography, University of Pittsburgh, Pittsburgh, Pennsyluania 15260

Single crystals of cadmium, zinc metallothionein ...

May 25, 1983 · THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 258: No, 10, Issue of May 25, pp. 6255-6257,1983 Printedm U S A . Single Crystals of Cadmium, Zinc Metallothionein* (Received for publication, December 6, 1982) Karen A. Melis, Daniel C. Carter, and Charles David Stout$ From the Department of Crystallography, University of Pittsburgh, Pittsburgh, Pennsyluania 15260 Dennis R.

(PDF) Crystals of Cadmium, Zinc Metallothionein

The interest in metallothionein and its involvement in heavy metal-induced nephropathy is a direct result of studies on the toxic metal, cadmium.

Cadmium, zinc, copper and metallothionein levels in human ...

高达10%返现 · The concentrations of cadmium, zinc, copper and metallothionein in the autopsy samples of liver among the inhabitants of Łódź (Poland) were determined. The cadmium levels were low in the range of 1.5 to 5.8 μg/g. The concentration of metallothionein determined by the Hg-method was high (0.160–1.665 μmol Hg/g); it was mainly a Zn-thionein. The percentage of hepatic zinc bound in

Metallothionein: a Cadmium- and Zinc-containing Protein ...

SUMDNLRY Metallothionein, a protein of small molecular weight, isolated from equine renal cortex contains 2.9 y. of cadmium, 0.6% of zinc, and 40/, of sulfur. The protein, homogeneous on ultracentrifugation, but containing minor impurities on electrophoresis, does not absorb radiation at and near 280 rnp, corresponding to 3 The Ag+ and p ...

Effects of cadmium and zinc on tissue levels of ...

Chung J, Nartey N and Cheria M (2010) Metallothionein Levels in Liver and Kidney of Canadians—A Potential Indicator of Environmental Exposure to Cadmium, Archives of Environmental Health: An International Journal, 10.1080/00039896.1986.9936704, 41:5, (319-323), Online publication date: 1

(PDF) Single crystals of cadmium, zinc metallothionein

Metallothionein is a widely distributed, extremely cysteine-rich, low-molecular-weight protein containing large amounts of cadmium and/or zinc. Metallothionein-1B is one of the two prinicipal ...

Single crystals of cadmium, zinc metallothionein.

THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 258: No, 10, Issue of May 25, pp. 6255-6257,1983 Printedm USA. Single Crystals of Cadmium, Zinc Metallothionein* (Received for publication, December 6, 1982) Karen A. Melis, Daniel C. Carter, and Charles David Stout$ From the Department of Crystallography, University of Pittsburgh, Pittsburgh, Pennsyluania 15260

(PDF) Crystals of Cadmium, Zinc Metallothionein

The interest in metallothionein and its involvement in heavy metal-induced nephropathy is a direct result of studies on the toxic metal, cadmium.

Cadmium, zinc, copper and metallothionein levels in human ...

The concentrations of cadmium, zinc, copper and metallothionein in the autopsy samples of liver among the inhabitants of Łódź (Poland) were determined. The cadmium levels were low in the range of 1.5 to 5.8 μg/g. The concentration of metallothionein determined by the Hg-method was high (0.160–1.665 μmol Hg/g); it was mainly a Zn-thionein. The percentage of hepatic zinc bound in the MT ...

Cadmium, zinc, copper, and metallothionein levels in the ...

Bern EM, Kaszper BW, Orlowski C, Piotrowski JK, Wójcik G, Zolnowska E (1993) Cadmium, zinc, copper and metallothionein levels in the kidney and liver of humans from central Poland. Environ Monitor Assess 25:1–13. Google Scholar 8. Bronisz H, Szost T, Lipska M, Zawada M (1983) Cadmium content in cigarettes (in Polish).

Metabolism of cadmium, zinc and copper in the rat kidney ...

Similarly, zinc deficiency affects primarily the complement of metals bound to metallothionein: zinc is markedly decreased and Cu is lowered to a smaller extent. Cadmium is unchanged. Control kidney, unexposed to Cd, normally contains a substantial amount of Zn,CuMT.

Dietary zinc reduces uptake but not metallothionein ...

Feb 09, 2010 · The aim of the present study was to determine the effect of zinc on cadmium kinetics and metallothionein induction in the springtail Orchesella cincta. Exposure experiments were conducted with cadmium only, zinc only, and cadmium + zinc. Metallothionein was isolated to determine zinc binding to or induction of this cadmium-binding protein.

Cadmium: cellular effects, modifications of biomolecules ...

Nov 01, 2006 · Basal and zinc-induced metallothionein in resistance to cadmium, cisplatin, zinc, and tertbutyl hydroperoxide: studies using MT knockout and antisense-downregulated MT in mammalian cells Toxicol. Sci. , 88 ( 2005 ) , pp. 602 - 613

(PDF) Cadmium, zinc, copper, and metallothionein levels in ...

ski C (1988) Cadmium, zinc, copper and metallothionein levels Although in Upper Silesia the average life span is a in human liver Int Arch Occup Environ Health 60:413-417 year shorter than elsewhere in Poland l44 l, it is claimed 6 Bern EM, Piotrowski JK, Koziara H (1989) Cadmium and that this is due mainly to circulatory system diseases and ...

Cadmium Transporters in the Kidney and Cadmium-Induced ...

Jan 09, 2015 · Cadmium transporters. Cadmium (Cd) is mostly bound to albumin in the circulation after absorption and then taken up by the liver. Some cadmium is bound to thiol-containing groups such as glutathione (GSH) and l-cysteine (Cys), which may be absorbed through both basolateral and apical sides of renal proximal tubular (PT) cells.In the liver, cadmium stimulates the synthesis of metallothioneins ...

Zinc as a countermeasure for cadmium toxicity | Acta ...

Apr 13, 2020 · Nephrotoxicity of cadmium-metallothionein: protection by zinc and role of glutathione. Toxicol Appl Pharmacol. 1998;151:276–82. CAS PubMed Google Scholar 116.

Cadmium | Cd - PubChem

The relationship between tissue levels of metallothionein and metal concentrations was assessed for zinc, copper, and cadmium in ten different organs from human autopsies and rats. Human autopsy specimens were obtained from ten males between the ages of 20 and 50 years within 2

Protection by Zinc-Metallothionein (ZnMT) against Cadmium ...

Jun 01, 1995 · Protection by Zinc-Metallothionein (ZnMT) against Cadmium-Metallothionein-Induced Nephrotoxicity 1. CATHERINE DORIAN, CATHERINE DORIAN Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center. Kansas City, Kansas 66160-7417. Search for other works by this author on:

Crystals of Cadmium, Zinc Metallothionein

Crystals of Cadmium, Zinc Metallothionein by Karen A. Melis,* Daniel C. Carter,* Charles D. Stout* and Dennis R. Winget Single crystals have been grown of Cd,Zn metallothionein isoform II from rat liver. The space group is P41212(P43212) with unit cell dimensions a = b = 31.0 A and c = 120.0 A, and one molecule in the crystallographic ...

Effects of Cadmium and Zinc on Tissue Levels of ...

Effects of Cadmium and Zinc on Tissue Levels of Metallothionein by S. Onosaka,* K. Tanaka* and M. G. Cheriant Although the induced synthesis of metallothionein (MT) after exposure to certain metals has been known for some time, there is little information on the quantitation of MT in various tissues.

Regulation of cadmium(2+)/zinc(2+)-stimulated ...

Intracellular metallothionein concentration and the rate of zinc or cadmium influx and MT mRNA accumulation in a CHO Cdr variant. Experimental Cell Research 1989 , 185 (1) , 166-175.

Electrospray ionization mass spectrometry of zinc, cadmium ...

Rupasri Mandal, Guifeng Jiang, Xing‐Fang Li, Direct evidence for co‐binding of cisplatin and cadmium to a native zinc‐ and cadmium‐containing metallothionein, Applied Organometallic Chemistry, 10.1002/aoc.502, 17, 9, (675-681), (2003).

Cadium, Zinc Metallothionein and Kidney Toxicity - David ...

Jul 01, 1995 · Ejnik, John; Shaw 3rd, C Frank; Petering, David H (2010) Mechanism of cadmium ion substitution in mammalian zinc metallothionein and metallothionein alpha domain: kinetic and structural studies. Inorg Chem 49:6525-34

Metallothionein - iThyroid

Since the level of cadmium is lower and that of zinc and copper higher in fetal than in maternal blood, this may suggest that placental MT may restrict cadmium while enhancing zinc and copper transport. Exp Gerontol 1993 Jan-Feb;28(1):17-38. Metallothionein expression and stress responses in aging human diploid fibroblasts.

Cadmium | Cd - PubChem

The relationship between tissue levels of metallothionein and metal concentrations was assessed for zinc, copper, and cadmium in ten different organs from human autopsies and rats. Human autopsy specimens were obtained from ten males between the ages of 20 and 50 years within 2

Cadmium Transporters in the Kidney and Cadmium-Induced ...

Jan 09, 2015 · Cadmium transporters. Cadmium (Cd) is mostly bound to albumin in the circulation after absorption and then taken up by the liver. Some cadmium is bound to thiol-containing groups such as glutathione (GSH) and l-cysteine (Cys), which may be absorbed through both basolateral and apical sides of renal proximal tubular (PT) cells.In the liver, cadmium stimulates the synthesis of metallothioneins ...

Cadmium: cellular effects, modifications of biomolecules ...

Nov 01, 2006 · Basal and zinc-induced metallothionein in resistance to cadmium, cisplatin, zinc, and tertbutyl hydroperoxide: studies using MT knockout and antisense-downregulated MT in mammalian cells Toxicol. Sci. , 88 ( 2005 ) , pp. 602 - 613

Métallothionéine — Wikipédia

Bibliographie. Adam V, Beklova M, Pikula J, Hubalek J, Trnkova L & Kizek R (2007) Shapes of differential pulse voltammograms and level of metallothionein at different animal species.Sensors, 7(10), 2419-2429. Fritsch C, Cosson R.P, Cœurdassier M, Raoul F, Giraudoux P, Crini N, de Vaufleury A & Scheifler R (2010) Responses of wild small mammals to a pollution gradient: host factors influence ...

(PDF) Unravelling the Role of Metallothionein on ...

Metallothionein Expression in P. sicula Embryos Incubated in Cadmium-Contaminated Soil metals, such as cadmium, varies greatly: in mammals, the placenta is the primary target [53], whereas The absence in oviparous of MT tetrapods, transcriptsisinconsidered vitellogenesis the gut, liver, and kidney the primary routeofofPodarcis embryosofmight ...

Metallothionein-I- and -II-deficient mice display ...

Sep 15, 2013 · Typically, MT-I/II bind zinc in the body, but MT-I and -II have a higher affinity for cadmium, and in the presence of cadmium, zinc that is bound to MT-I/II is displaced . Pathologies associated with MT-I/II −/− mice result in many instances from increased sensitivity to the toxic effects of cadmium and other redox-active molecules ( 30 ).

The Metallothionein/Thionein System: An Oxidoreductive ...

Dec 29, 2008 · This zinc transfer has been speculated to regulate gene expression through activation or inhibition of DNA binding. 15, 28 In fact, zinc can be shuttled in both directions—from MT to zinc apo enzymes and from zinc enzymes to metal-free metallothionein (thionein, T). Zinc transfer from MT to mitochondrial aconitase has also been demonstrated ...